Trauma Center: Second Opinion is a simulation video game developed by Atlus for the Wii. The second entry in the Trauma Center series, Second Opinion is a remake of the Nintendo DS title Trauma Center: Under the Knife (2005). The game was released in North America and Japan in 2006 by Atlus as a console launch title, and in other regions in 2007 by Nintendo. Set in a near future where medical science can cure previously incurable diseases, the story follows young surgeon Derek Stiles as he uses his mystical "Healing Touch" to treat a new disease dubbed GUILT. Second Opinion expands on the original narrative through the perspective of Naomi Kimishima, another doctor with the Healing Touch. Gameplay combines surgical simulation with a story told as a visual novel, with operations and control options reworked for the Wii hardware. The game began development in early 2006. Production was stressful due to a small team and tight development period. The character Naomi was added to help set the game apart from the Nintendo DS original. The localization was done by Atlus USA, who focused on tightening the original script and merging it with the new narrative. The game was positively reviewed by journalists, who praised its implementation of the Wii control scheme. It was also a commercial success, selling over 400,000 units overseas.