A sequel was first revealed to be in development in May 2022, when Norman Reedus participated in an interview with the outlet Leo Edit to discuss his work on the game. Speaking to Ilaria Urbinati, Reedus exclaimed, "We just started work on the second one". Later in the interview, he would reminisce about how, "the game came out, and it just won all these awards, and it was a huge thing", before reiterating that the development team had "just started part two of that". In response, game writer and director Hideo Kojima would post a series of photos on Twitter, cheekily depicting him punishing Reedus for confirming the game's existence while telling him, "Go to your private room, my friend". The sequel was teased with images revealed at numerous game expos featuring Elle Fanning, Shioli Kutsuna, and Léa Seydoux. A first trailer for Death Stranding 2 (stylized as DS2 and clarified to be a working title) was revealed at The Game Awards 2022, with the aforementioned teased actors confirmed as well as Troy Baker returning from the first game.

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